An Efficient Approach to the Synthesis of Hydrazinyl Pseudo-Peptides

作者:Fathi Vaezeh; Ramezanpour Sorour; Balalaie Saeed*; Rominger Frank; Bijanzadeh Hamid Reza
来源:Helvetica Chimica Acta, 2014, 97(12): 1630-1637.
DOI:10.1002/hlca.201400061

摘要

New hydrazinyl pseudo-peptides have been obtained from Ugi four-component reaction (4CR). The 5-hydrazinyl-5-oxopentanoic acids used as starting materials were prepared by the reaction of hydrazides with anhydrides. Mild reaction conditions, high atom economy, bond-forming efficiency, and easy workup are advantages of this approach. The products have four amide bonds and high potential for H-bonding.

  • 出版日期2014-12