An Improved Procedure for the Preparation of [Bis(2,2,2-trifluoroethyl)phosphono]acetic Acid

作者：Prado Viviana da Silva; Burtoloso Antonio Carlos B^*

来源：Synthesis, 2010, 2010(2): 361-363.

DOI：10.1055/s-0029-1217086

• [bis(2,2,2-trifluoroethyl)phosphono]acetic acid
• Horner-Wadsworth-Emmons (HWE) reaction
• Michaelis-Becker reaction
• Still-Gennari reagents

A different and improved procedure for the preparation of [bis(2,2,2-trifluoroethyl)phosphono]acetic acid in just one step from bis(2,2,2-trifluoroethyl)phosphonate is described. The protocol employs a Michaelis-Becker reaction between commercially available bis(2,2,2-trifluoroethyl) phosphonate and bromoacetic acid, furnishing [bis(2,2,2-trifluoroethyl)phosphono]acetic acid in 50-54% yield.

• 出版日期2010-1