Minimizing opioid use after acute major trauma

作者：Oyler Douglas^*; Bernard Andrew C; VanHoose Jeremy D; Parli Sara E; Ellis C Scott; Li David; Procter Levi D; Chang Phillip K

来源：American Journal of Health-System Pharmacy, 2018, 75(3): 105-110.

DOI：10.2146/ajhp161021

• NSAID
• opioid
• pain management
• trauma

Purpose. Results of an initiative at an academic medical center to reduce prescription opioid use in patients with acute traumatic injuries are reported.
Methods. In 2014, the University of Kentucky Hospital trauma service implemented a pain management strategy consisting of patient and provider education emphasizing the use of nonopioid analgesics to minimize opioid use without compromising analgesia effectiveness. To assess the impact of the initiative, a retrospective analysis of data on cohorts of patients admitted with acute trauma before (n = 489) and after (n = 424) project implementation was conducted. The primary endpoint was opioid use (prescribed daily milligram morphine equivalents [MME]) at discharge. Secondary endpoints included inpatient opioid and alternative analgesic use, pain control, ileus development, length of stay, and discharge disposition.
Results. Compared with the preintervention cohort, the postintervention cohort had a lower median daily discharge MME overall (45 MME versus 90 MME, p < 0.001); after stratification of MME data by baseline opioid use, this finding held true only for patients with no opioid prescription at admission. Although utilization of gabapentinoids, skeletal muscle relaxants, and clonidine increased during the postintervention period, inpatient opioid use did not differ significantly in the 2 cohorts. Utilization of both nonsteroidal antiinflammatory drugs and acetaminophen was lower in the postintervention cohort versus the preintervention cohort.
Conclusion. Targeted provider and patient education on minimizing opioid use was associated with a reduction in MME on discharge from the hospital after traumatic injury.

• 出版日期2018-2-1