Normalization of FoxP3(+) Regulatory T Cells in Response to Effective Antiretroviral Therapy

作者：Montes Martin; Sanchez Cesar; Lewis Dorothy E; Graviss Edward A; Seas Carlos; Gotuzzo Eduardo; White A Clinton Jr^*

来源：Journal of Infectious Diseases, 2011, 203(4): 496-499.

DOI：10.1093/infdis/jiq073

Regulatory T cells (Tregs) blunt uncontrolled immune responses. In advanced human immunodeficiency virus (HIV) infection, the total number of Tregs is decreased, but the proportion of T cells with a regulatory phenotype is highly variable. We studied CD4(+)CD25(+)FoxP3(+) T cells from patients successfully treated with combination antiretroviral therapy (ART). The proportion of CD4(+)CD25(+)FoxP3(+) cells transiently increased and then decreased from a median of 13% at baseline to 5.1% at 48 weeks, similar to values in normal subjects. These data suggest that with effective therapy, the regulatory cell numbers normalize, and that the inflammatory signals driving their production may also abate.

• 出版日期2011-2-15
• 单位河北医科大学