NMR assignments and histone specificity of the ING2 PHD finger

作者：Pena Pedro V; Musselman Catherine A; Kuo Alex J; Gozani Or; Kutateladze Tatiana G^*

来源：Magnetic Resonance in Chemistry, 2009, 47(4): 352-358.

DOI：10.1002/mrc.2390

• NMR
• histone
• chromatin
• PHD finger
• resonance assignment

The ING2 plant homeodomain (PHD) finger is recruited to the nucleosome through specific binding to histone H3 trimethylated at lysine 4 (H3K4me3). Here, we describe backbone and side chain assignments of the ING2 PHD finger, analyze its binding to the unmodified and modified histone and p53 peptides, and map the histone H3 and H3K4me3 binding sites based on chemical shift perturbation analysis.

• 出版日期2009-4