Multiple biological activities and molecular docking studies of newly synthesized 3-(pyridin-4-yl)-1H-pyrazole-5-carboxamide chalcone hybrids

作者：Sribalan Rajendran; Banuppriya Govindharasu; Kirubavathi Maruthan; Jayachitra A; Padmini Vediappen^*

来源：Bioorganic & Medicinal Chemistry Letters, 2016, 26(23): 5624-5630.

DOI：10.1016/j.bmcl.2016.10.075

• Pyrazole carboxamide
• Chalcone
• Antibacterial
• Anti-inflammatory
• Antioxidant

A series of fifteen new chemical entities, 3-(pyridin-4-yl)-1H-pyrazole-5-carboxamide chalcones (6a-o), were synthesized as new hybrids with enriched biological activities compared to their parent molecules. The compounds were characterized by H-1 NMR, C-13 NMR, Mass and IR spectral studies. Their antibacterial, anti-inflammatory and antioxidant activities have been evaluated. These compounds showed moderate to good antibacterial, anti-inflammatory and antioxidant activities. The molecular docking analysis was performed with cyclooxygenase enzyme to ascertain the probable binding model.

• 出版日期2016-12-1