A click chemistry approach to identify protein targets of cancer chemopreventive phenethyl isothiocyanate

作者：Fu Ying; Mi Lixin; Sanda Miloslav; Silverstein Shana; Aggarwal Monika; Wang Deyun; Gupta Pankaj; Goldman Radoslav; Appella Daniel H; Chung Fung Lung^*

来源：RSC Advances, 2014, 4(8): 3920-3923.

DOI：10.1039/c3ra46849f

Here we report the identification of protein targets of chemopreventive phenethyl isothiocyanate (PEITC) via "click" chemistry in the A549 human lung cancer cell line, using a novel alkyne-tagged PEITC which was also found to show potent in vitro anticancer activity.

• 出版日期2014
• 单位NIH