Association of c.461G > A genetic variant of OGG1 gene with pancreatic cancer susceptibility in Chinese

作者：Zhao, Z. M.^*; Li, C. G.; Hu, M. G.; Zhao, G. D.; Liu, R.

来源：Genetics and Molecular Research, 2014, 13(3): 7256-7261.

DOI：10.4238/2014.September.5.10

• Pancreatic cancer
• OGG1 gene
• Risk factors
• Single nucleotide polymorphisms
• Cancer susceptibility

This study aimed to evaluate the potential association of single nucleotide polymorphisms of the 8-oxoguanine DNA glycosylase gene (OGG1) with susceptibility to pancreatic cancer (PC). A total of 764 Chinese Han subjects were recruited in this study. The polymerase chain reaction-restriction fragment length polymorphism and DNA sequencing methods were used to detect the genotype of c. 461G>A genetic variant of OGG1. The genotype and allele frequencies were statistically different in PC patients compared with cancer-free controls. The AA genotype was statistically associated with increased PC susceptibility compared to GG wild genotype (AA vs GG, OR = 2.62, 95% CI = 1.48-4.63,.2 = 11.46, P = 0.001). Allele A could contribute to the increased risk of PC (A vs G, OR = 1.35, 95% CI = 1.08-1.69,.2 = 6.86, P = 0.009). Our data indicated that the c. 461G>A genetic variant of the OGG1 gene was associated with susceptibility to PC in a Chinese Han population.

• 出版日期2014
• 单位中国人民解放军总医院