Antibiotic Detection in Urine Using Electrochemical Sensors Based on Vertically Aligned Carbon Nanotubes

作者：Moraes Fernando C; Silva Tiago A; Cesarino Ivana^*; Lanza Marcos R V; Machado Sergio A S

来源：Electroanalysis, 2013, 25(9): 2092-2099.

DOI：10.1002/elan.201300261

• Carbon nanotubes
• Vertical alignment
• Levofloxacin
• Urine samples

A sensitive way to determine levofloxacin using a sensor based on vertical aligned carbon nanotubes is described. The morphology and the electrochemical performance of the electrodes were characterised by atomic force microscopy, cyclic voltammetry and square wave voltammetry. A scan-rate study and electrochemical impedance spectroscopy showed that the levofloxacin oxidation product is adsorbed on the electrode surface. Differential pulse voltammetry in phosphate-buffer solution allowed the development of a method to determine levofloxacin levels in the range of 1.0-10.0 mu molL(-1), with a detection limit of 75.2nmolL(-1). The proposed sensor was successfully applied in the determination of levofloxacin in urine, and the obtained results were in full agreement with those from the HPLC procedure.

• 出版日期2013-9