Autophagy and bacterial infection: an evolving arms race

作者：Choy Augustine; Roy Craig R^*

来源：Trends in Microbiology, 2013, 21(9): 451-456.

DOI：10.1016/j.tim.2013.06.009

• autophagy
• xenophagy
• intracellular bacteria

Autophagy is an important membrane transport pathway that is conserved among eukaryotic cells. Although first described as an intracellular catabolic pathway used to break down self-components, autophagy has been found to play an important role in the elimination of intracellular pathogens. A variety of host mechanisms exist for recognizing and targeting intracellular bacteria to autophagosomes. Several intracellular bacteria have evolved ways to manipulate, inhibit, or avoid autophagy in order to survive in the cell. Thus, the autophagy pathway can be viewed as an evolutionarily conserved host response to infection.

• 出版日期2013-9