A CONVENIENT SYNTHETIC METHOD OF ISOXAZOLE DERIVATIVES USING COPPER(II) NITRATE

作者:Itoh Ken ichi*; Aoyama Tadashi; Satoh Hiroaki; Hasegawa Kenta; Meguro Natsumi; Horiuchi Akira C; Takido Toshio; Kodomari Mitsuo
来源:Heterocycles, 2014, 89(6): 1473-1482.
DOI:10.3987/COM-14-12979

摘要

3-Acetylisoxazoles were synthesized by the reaction of alkenes or alkynes in acetone as solvent with copper(II) nitrate and formic acid. In the case of ethyl acetate as solvent, 3-benzoylisoxazoles were yielded by the reaction of alkynes and acetophenone with copper(II) nitrate and nitric acid. This synthetic method provides a convenient production of isoxazole derivatives.

  • 出版日期2014-6-1