Aminodextran polymer-functionalized reactive magnetic emulsions for potential theranostic applications

作者：Lima Tenorio Michele K; Pineda Edgardo A Gomez; Ahmad Nasir M; Agusti Geraldine; Manzoor Sadia; Kabbaj Dounia; Fessi Hatem; Elaissari Abdeihamid^*

来源：Colloids and Surfaces B: Biointerfaces , 2016, 145: 373-381.

DOI：10.1016/j.colsurfb.2016.05.020

• Iron oxide
• Magnetic emulsion
• Adsorption
• MRI
• Hyperthermia

Aminodextran (AMD) polymer was prepared via chemical grafting of hexamethylenediamine on oxidized dextran. Magnetic latex particles were successfully obtained by adsorption of positively charged AMD on negatively charged submicron magnetic emulsion. The adsorbed amount was found to be ranged from 20 to 1280 mg of AMD per gram of dried magnetic dispersion. The AMD-coated magnetic emulsions were characterized by positive zeta potential in the pH range from 3 to 9 compared to bare seed magnetic emulsion. All the samples showed to be superparamagnetic property, even after the adsorption of the polymer. The developed magnetic submicron particles exhibited good potential for in vivo biomedical diagnosis applications as demonstrated by their higher T-2 contrast-ability compared to Gd in magnetic resonance imaging (MRI) and hyperthermia.

• 出版日期2016-9-1