Antibacterial anti-oxidant electroactive injectable hydrogel as self-healing wound dressing with hemostasis and adhesiveness for cutaneous wound healing

作者：Zhao, Xin; Wu, Hao; Guo, Baolin^*; Dong, Ruonan; Qiu, Yusheng; Ma, Peter X.

来源：Biomaterials, 2017, 122: 34-47.

DOI：10.1016/j.biomaterials.2017.01.011

• Antibacterial
• Electroactivity
• Conductive hydrogel dressing
• Self-healing
• Full thickness skin defect model
• Wound healing

Injectable self-healing hydrogel dressing with multifunctional properties including anti-infection, anti oxidative and conductivity promoting wound healing process will be highly desired in wound healing application and its design is still a challenge. We developed a series of injectable conductive self-healed hydrogels based on quaternized chitosan-g-polyaniline (QCSP) and benzaldehyde group functionalized poly(ethylene glycol)-co-poly(glycerol sebacate) (PEGS-FA) as antibacterial, anti-oxidant and electroactive dressing for cutaneous wound healing. These hydrogels presented good self-healing, electroactivity, free radical scavenging capacity, antibacterial activity, adhesiveness, conductivity, swelling ratio, and biocompatibility. Interestingly, the hydrogel with an optimal crosslinker concentration of 1.5 wt% PEGS-FA showed excellent in vivo blood clotting capacity, and it significantly enhanced in vivo wound healing process in a full-thickness skin defect model than quaternized chitosan/PEGS-FA hydrogel and commercial dressing (Tegaderm (TM) film) by upregulating the gene expression of growth factors including VEGF, EGF and TGF-beta and then promoting granulation tissue thickness and collagen deposition. Taken together, the antibacterial electroactive injectable hydrogel dressing prolonged the lifespan of dressing relying on self-healing ability and significantly promoted the in vivo wound healing process attributed to its multifunctional properties, meaning that they are excellent candidates for full-thickness skin wound healing.

• 出版日期2017-4
• 单位西安交通大学