A comparative study of low-fluence 1064-nm Q-switched Nd:YAG laser with or without chemical peeling using Jessner%26apos;s solution in melasma patients

作者：Lee Dan Bi; Suh Ho Seok; Choi Yu Sung^*

来源：Journal of Dermatological Treatment, 2014, 25(6): 523-528.

DOI：10.3109/09546634.2013.848261

• 1064-nm Q-switched Nd:YAG laser
• Jessner%26apos
• s solution
• melasma

Background: Although low-fluence 1064-nm Q-switched Nd:YAG laser (QSNYL) is widely used for the treatment of melasma, multiple treatments are necessary for clinical improvement. Superficial chemical peeling using Jessner%26apos;s solution has been used for treatment of melasma conventionally. %26lt;br%26gt;Objectives: To evaluate the additional therapeutic effect and adverse effects of Jessner%26apos;s peel when combined with 1064-nm QSNYL for melasma patients in a double-blind, placebo-controlled design. %26lt;br%26gt;Methods: Total of 52 patients were included. Patients who received 10 sessions of 1064-nm QSNYL plus chemical peeling with placebo (group A) in a two-week interval and those who received 10 sessions of 1064-nm QSNYL plus chemical peeling with Jessner%26apos;s solution (group B) in a two-week interval were analyzed. Responses were evaluated using the Melasma Area and Severity Index (MASI) score, physician%26apos;s global assessment (PGA) and subjective self-assessment. Results: At 8 weeks, the mean MASI score decreased from 8.68 +/- 4.06 to 8.60 +/- 3.88 in group A and from 8.98 +/- 3.72 to 7.13 +/- 2.57 in group B, showing a significant difference (p%26lt;0.001). But at 20 weeks, there was no significant difference on reduction of MASI, self-assessment and PGA between the two groups. No serious adverse effects were reported with the additional Jessner%26apos;s peeling. %26lt;br%26gt;Conclusion: This study suggests Jessner%26apos;s peel is a safe and effective method in the early course of treatment for melasma when combined with low-fluence 1064-nm Q-switched Nd: YAG laser.

• 出版日期2014-12