Acute toxicity and responses of antioxidant systems to 1-methyl-3-octylimidazolium bromide at different developmental stages of goldfish

作者：Li, Xiao-Yu^*; Zeng, Shi-Hu; Dong, Xiang-Yi; Ma, Jun-Guo; Wang, Jian-Ji

来源：Ecotoxicology, 2012, 21(1): 253-259.

DOI：10.1007/s10646-011-0785-z

• 1-Methyl-3-octylimidazolium bromide
• Carassius auratus
• Developmental stage
• Toxicity
• Antioxidant system

Acute toxicity of 1-methyl-3-octylimidazolium bromide ([C(8)mim]Br) to goldfish at different developmental stages and responses of the antioxidant system in adult goldfish were evaluated in the present study. The results indicate that post-embryonic developmental toxicity of [C(8)mim]Br on goldfish is developmental-stage dependent. The juvenile and larva goldfish are more sensitive to [C(8)mim]Br-toxicity than the adult fish. Histological observations in adult goldfish reveal that acute [C(8)mim]Br exposure damages the hepatopancreas, intestines, and kidneys, indicating that these are possible target organs of [C(8)mim]Br toxicity in goldfish. Subsequent biochemical assays in adult goldfish show that [C(8)mim]Br also induces changes in the activities of the superoxide dismutase, catalase, glutathione peroxidase, and glutathione content of fish hepatopancreas. These results suggest that [C(8)mim]Br exposure may induce oxidant stress and lipid peroxidation in hepatopancreas of adult goldfish. In addition, we also find that [C(8)mim]Br causes a remarkable increase in malondialdehyde (MDA) levels in the hepatopancreas of adult goldfish, and thus we think that the MDA level change can be a biomarker of [C(8)mim]Br toxicity in goldfish. The present study indicates that ionic liquids can be a threat to the survival, growth, and development of the fish population once they are accidentally leaked into aquatic ecosystems.

• 出版日期2012-1
• 单位河南师范大学