Association of sodium intake with insulin resistance in Korean children and adolescents: the Korea National Health and Nutrition Examination Survey 2010

作者：Kim Yong Min; Kim So Hyun; Shim Young Suk^*

来源：Journal of Pediatric Endocrinology & Metabolism, 2018, 31(2): 117-125.

DOI：10.1515/jpem-2017-0362

• children
• HOMA-IR
• insulin resistance
• QUICKI
• sodium intake
• urinary sodium to urinary creatinine ratio

Background: This study aimed to evaluate the relationship between sodium intake and insulin resistance indices.
Methods: A total of 718 Korean children and adolescents (411 boys) aged 10-18 years who participated in the Korea National Health and Nutrition Examination Survey (KNHANES) were included in the study. The urinary sodium to urinary creatinine ratio was used as a surrogate for sodium intake. The homeostatic model assessment of insulin resistance (HOMA-IR) and the quantitative insulin sensitivity check index (QUICKI) were used as indices of insulin resistance.
Results: The mean urinary sodium to urinary creatinine ratio was 11.34 in males and 10.17 in females. The urinary sodium to urinary creatinine ratio was significantly positively correlated with HOMA-IR (r = 0.165, p < 0.001) and inversely correlated with QUICKI (r = -0.181, p < 0.001) in Pearson's correlation analyses. In a multivariate linear regression analysis, the urinary sodium to urinary creatinine ratio was independently and significantly positively associated with HOMA-IR (beta = 0.073, p = 0.018) and significantly inversely associated with QUICKI (beta = -0.080, p = 0.007) after adjustment for possible confounders. HOMA-IR was independently and significantly positively associated with the urinary sodium to urinary creatinine ratio (beta = 0.087, p = 0.018), whereas QUICKI was independently and significantly negatively associated with the urinary sodium to urinary creatinine ratio (beta = -0.097, p = 0.009) after controlling for confounders.
Conclusions: Our results suggest that sodium intake, as estimated by the urinary sodium to urinary creatinine ratio, may be independently associated with insulin resistance in children and adolescents.

• 出版日期2018-2