Anti-Hyperglycemic Effect of Fermented Ginseng in Type 2 Diabetes Mellitus Mouse Model

作者：Jeon Woo Jin; Oh Jin Sun; Park Myeong Soo; Ji Geun Eog^*

来源：Phytotherapy Research, 2013, 27(2): 166-172.

DOI：10.1002/ptr.4706

• type 2 diabetes
• fermented ginseng extract
• mice
• anti-hyperglycemia
• antiinflammation

Ginseng has shown an efficacy in preventing and managing various health conditions. This study aimed to evaluate the effect of the fermented ginseng extract (FGE) in type 2 diabetes mellitus murine model. FGE was provided to male C57BL/ksJ-db/db mice for 8weeks at 0.1% (w/w) dose in contrast to water for the control group. Potential anti-diabetic mechanisms were investigated with blood glucose, serum insulin, serum adiponectin, hemoglobin A1c (HbA1c), glucose tolerance, insulin secretion assay, quantitative real-time polymerase chain reaction, and hematoxylineosin staining. Compared with the control group, the FGE group had lower levels of blood glucose after 6 and 9h fasting, HbA1c, and the area under the curve in an oral glucose tolerance test and higher levels of adiponectin and serum insulin (p<0.05). The FGE group had higher levels of peroxisome proliferator-activated receptor gamma 2 and glucose transporter protein 2 mRNAs, a lower level of tumor necrosis factor- (TNF-) (p<0.05), and less lymphocytes in pancreas than the control group had. The FGE exerted anti-diabetic effects in type 2 diabetic mice.

• 出版日期2013-2