A concise synthetic approach toward tamiflu (oseltamivir phosphate): cis-aziridine as the key synthon and RCM

作者：Chavan Subhash P^*; Chavan Prakash N; Khairnar Lalit B

来源：RSC Advances, 2014, 4(22): 11417-11419.

DOI：10.1039/c3ra47210h

The key synthon cis-aziridine has been efficiently utilised for the synthesis of oseltamivir phosphate, using Wittig olefination, Barbier addition, Mitsunobu reaction and ring closing metathesis (RCM) as key essentials.

• 出版日期2014