Direct Access to α-Trifluoromethyl Enones via Efficient Copper-Catalyzed Trifluoromethylation of Meyer-Schuster Rearrangement

作者：Xiong, Ya-Ping; Wu, Ming-Yue; Zhang, Xiang-Yu; Ma, Can-Liang; Huang, Lin; Zhao, Li-Jiao; Tan, Bin^*; Liu, Xin-Yuan

来源：Organic Letters, 2014, 16(3): 1000-1003.

DOI：10.1021/ol403741m

• PD(II)-CATALYZED ORTHO-TRIFLUOROMETHYLATION
• ELECTROPHILIC TRIFLUOROMETHYLATION
• OXIDATIVE TRIFLUOROMETHYLATION
• OLEFINIC TRIFLUOROMETHYLATION
• PHOTOREDOX CATALYSIS
• PROPARGYLIC ALCOHOLS
• UNACTIVATED OLEFINS
• ALLYLIC ALCOHOLS
• BOND FORMATION
• ALKENES

A novel domino copper-catalyzed trifluoromethylated Meyer-Schuster rearrangement reaction with Togni's reagent was developed, leading to a-trifluormethyl (CF3) enone products with moderate to good yields. Furthermore, alpha-CF3 enones can be transformed toward important trifluoromethyl heterocyclic motifs in a one-pot version.

• 出版日期2014-2-7
• 单位南方科技大学