Antitumor activities on HL-60 human leukemia cell line, molecular docking, and quantum-chemical calculations of some sulfonamide-benzoxazoles

作者：Oksuzoglu Emine^*; Ertan Bolelli Tugba; Can Hatice; Tarhan Mehtap; Ozturk Kamile; Yildiz Ilkay^*

来源：Artificial Cells, Nanomedicine and Biotechnology, 2017, 45(7): 1388-1396.

DOI：10.1080/21691401.2016.1241796

• Antitumor activity
• benzoxazole
• sulfonamide
• HL-60 human leukemia cell line
• molecular docking
• quantum chemical calculations
• topoisomerase II

We previously synthesized some novel benzoxazole derivatives-containing sulfonamide. In this study, the compounds were investigated for their antitumor activities against the HL-60 human leukemia cells, using the MTT assay. Moreover, quantum chemical calculations using the DFT methods were applied for understanding the difference in antitumor activity. Additionally, molecular docking into active site of the DNA Topo II enzyme was performed on 3QX3. PDB file in order to find out possible mechanism of antitumor effect.
According to all obtained results showed that compounds 1b, 1c, and 1d could be potential drug candidates as new antitumor agents, and are promising for cancer therapy.

• 出版日期2017