A phase I study of anti-inflammatory therapy with rilonacept in adolescents and adults with type 1 diabetes mellitus

作者：White Perrin C; Adhikari Soumya; Grishman Ellen K; Sumpter Kathryn M

来源：Pediatric Diabetes, 2018, 19(4): 788-793.

DOI：10.1111/pedi.12634

• cytokine
• gene expression
• immunomodulation
• innate immunity
• interleukin-1 beta

Background: The innate immune system may be activated around the time of diagnosis of type 1 diabetes (T1D). Components of this system, including cytokines such as interleukin-1 beta (IL-1 beta) represent potential therapeutic targets for disease modifying therapy.
Objective: We conducted a phase 1 trial of rilonacept, an IL-1 cytokine trap, in patients with T1D.
Subjects and methods: Thirteen T1D patients (10 males) with median age (interquartile range, IQR) of 17 years (16-18), a median (IQR) of 5 months (5-7) since diagnosis. Rilonacept was administered subcutaneously for 26 weeks. Incidence of infections was the primary end-point.
Results: There were 85 adverse events; 13 were Grade 2, of which 9 (8 infectious) were judged possibly related to the drug. The mean (SD) C-peptide on 2-hour mixed meal tolerance tests decreased from 0.87 (0.42) to 0.59 (0.29) ng/mL (P=.01 by paired t test) during 6months on treatment. Hemoglobin A1c (HbA1c) increased from 6.8 (1.1) to 7.3 (1.1) (P=.05), but there was not a significant change in daily insulin dose (0.41 +/- 0.23 to 0.47 +/- 0.18), or in insulin dose-adjusted HbA1c (IDAA1c, 8.4 +/- 1.8 to 9.0 +/- 1.5). Subjects in remission, defined as HbA1c <6.5 and a total daily insulin dose <0.5 units/kg/24 h, decreased from 5 to 4. There were no significantly differentially expressed genes in peripheral blood leukocytes before and after rilonacept.
Conclusions: Rilonacept treatment for 6 months is well-tolerated in individuals with T1D of recent onset, but is unlikely to be efficacious as a single agent in preserving beta cell function.

• 出版日期2018-6