科研之友
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摘要
We report a cheap and simple method for the acetylation of a variety of amines using catalytic acetic acid and either ethyl acetate or butyl acetate as the acyl source. Catalyst loadings as low as 10 mol% afforded acetamide products in excellent yields at temperatures ranging from 80-120 degrees C. The methodology can also be successfully applied for the synthesis of a broad range of other amides, including the formation of formamides at 20 degrees C.
- 出版日期2017
