A Novel Synthesis of 1,4,7,10-Tetraazacyclododecane by the Tandem Reaction of a Vinylsulfonium Salt

作者：Huang, Rui; Xie, Chunsong^*; Huang, Lin; Liu, Jinhua

来源：Letters in Organic Chemistry, 2013, 10(3): 195-198.

DOI：10.2174/1570178611310030009

• 1,4,7,10-Tetraazacyclododecane
• MRI
• Tandem Reaction
• Vinylsulfonium

1,4,7,10-Tetraazacyclododecane was synthesized through 4 steps by using easily available diphenylsulfonium triflate as a key annulation reagent. The reaction condition was very mild and the yield was high. After oxidation and hydrolysis, 1,4,7,10-Tetraazacyclododecane, which had been proven to be the pivotal precursor for a wide range of MRI contrast reagents, was produced in an overall yield of 31%.

• 出版日期2013-3
• 单位杭州师范大学