The expression of p21 is upregulated by forkhead box A1/2 in p53-null H1299 cells

作者：An Joo Hee; Jang Sang Min; Kim Jung Woong; Kim Chul Hong; Song Peter I^*; Choi Kyung Hee

来源：FEBS LETTERS, 2014, 588(21): 4065-4070.

DOI：10.1016/j.febslet.2014.09.033

• Transcription factor FOXA1/2
• p21
• Trichostatin A
• Target gene
• p53-Independent pathway

The expression of the cell cycle inhibitor p21 is increased in response to various stimuli and stress signals through p53-dependent and independent pathways. We demonstrate in this study that forkhead box A1/2 (FOXA1/2) is a crucial transcription factor in the activation of p21 transcription via direct binding to the p21 promoter in p53-null H1299 lung carcinoma cells. In addition, histone deacetylase inhibitor trichostatin A (TSA)-mediated upregulation of p21 expression was repressed by knockdown of FOXA1/2 in H1299 cells. Consequently, these results suggest that FOXA1/2 is required for p53-independent p21 expression.

• 出版日期2014-11-3
• 单位NIH