A Population-Based Study on the Association between Gastric Ulcers and Erectile Dysfunction in Taiwan

作者：Keller Joseph J; Lin Hsiao Yu^*; Chung Shiu Dong; Lin Herng Ching

来源：The Journal of Sexual Medicine, 2012, 9(3): 686-693.

DOI：10.1111/j.1743-6109.2011.02614.x

• Erectile Dysfunction
• Gastric Ulcers
• Epidemiology

Introduction. While erectile dysED) and cardiovascular disease have long been known to share endothelial dysfunction as a common contributory underlying mechanism, little research has been conducted taking endothelial dysfunction as common ground to investigate the potential association between ED and gastric ulcers (GUs). %26lt;br%26gt;Aim. This population-based case-control study aimed to investigate the association of ED with GU. %26lt;br%26gt;Methods. This study used data from the Longitudinal Health Insurance Database 2000 in Taiwan. The study group comprised 6,906 patients who visited ambulatory care centers or were hospitalized with a diagnosis of ED. The comparison group was 20,718 randomly selected enrollees. Conditional logistic regression was used to examine associations between ED and prior GU. %26lt;br%26gt;Main Outcome Measure. The prevalence and risk between cases and controls were calculated of having been previously diagnosed with GU. %26lt;br%26gt;Results. Of the sampled subjects, 3,861 (14%) were diagnosed before the index date, 1,358 (19.7%) were cases, and 2,503 (12.1%) were controls (P %26lt; 0.001). After adjusting for hypertension, diabetes, hyperlipidemia, renal disease, coronary heart disease, obesity, alcohol abuse/alcohol dependence syndrome, and socioeconomic status (SES), conditional logistic regression analysis revealed that cases were more likely to have been diagnosed with GU than controls (odds ratio [OR] = 1.65, 95% confidence interval [CI] = 1.53-1.77). Stratification by age revealed that the youngest group (18-29) of ED patients had the most increased likelihood of having been previously diagnosed with GU when compared with matched controls (OR = 4.12, 95% CI = 2.41-7.03). The likelihood decreased with age, with the oldest group of ED patients having the least increased likelihood of prior GU when compared with matched controls (OR = 1.44, 95% CI = 1.23-1.68). %26lt;br%26gt;Conclusion. Our findings suggest a positive association between prior GU and a subsequent diagnosis with ED. Keller JJ, Lin H-Yu, Chung S-D, and Lin H-C. A population-based study on the association between gastric ulcers and erectile dysfunction in Taiwan. J Sex Med 2012; 9: 686-693.

• 出版日期2012-3