Diagnostic performance of Ga-68-PSMA-11 (HBED-CC) PET/CT in patients with recurrent prostate cancer: evaluation in 1007 patients

作者：Afshar-Oromieh, Ali^*; Holland-Letz, Tim; Giesel, Frederik L.; Kratochwil, Clemens; Mier, Walter; Haufe, Sabine; Debus, Nils; Eder, Matthias; Eisenhut, Michael; Schaefer, Martin; Neels, Oliver; Hohenfellner, Markus; Kopka, Klaus; Kauczor, Hans-Ulrich; Debus, Juergen; Haberkorn, Uwe

来源：European Journal of Nuclear Medicine and Molecular Imaging, 2017, 44(8): 1258-1268.

DOI：10.1007/s00259-017-3711-7

• Prostate cancer
• PET/CT
• Positron emission tomography
• PSMA
• Prostate-specific membrane antigen

Since the clinical introduction of Ga-68-PSMA-11 PET/CT, this imaging method has rapidly spread and is now regarded as a significant step forward in the diagnosis of recurrent prostate cancer (PCa). The aim of this study was to analyse the influence of several variables with possible influence on PSMA ligand uptake in a large cohort. @@@ We performed a retrospective analysis of 1007 consecutive patients who were scanned with Ga-68-PSMA-11 PET/CT (1 h after injection) from January 2014 to January 2017 to detect recurrent disease. Patients with untreated primary PCa or patients referred for PSMA radioligand therapy were excluded. The possible effects of different variables including PSA level and PSA doubling time (PSA(DT)), PSA velocity (PSA(Vel)), Gleason score (GSC, including separate analysis of GSC 7a and 7b), ongoing androgen deprivation therapy (ADT), patient age and amount of injected activity were evaluated. @@@ In 79.5% of patients at least one lesion with characteristics suggestive of recurrent PCa was detected. A pathological (positive) PET/CT scan was associated with PSA level and ADT. GSC, amount of injected activity, patient age, PSA(DT) and PSA(Vel) were not associated with a positive PET/CT scan in multivariate analysis. @@@ Ga-68-PSMA-11 PET/CT detects tumour lesions in a high percentage of patients with recurrent PCa. Tumour detection is clearly associated with PSA level and ADT. Only a tendency for an association without statistical significance was found between higher GSC and a higher probability of a pathological PET/CT scan. No associations were found between a pathological Ga-68-PSMA-11 PET/CT scan and patient age, amount of injected activity, PSA(DT) or PSA(Vel.).

• 出版日期2017-8