Asymmetric addition of diethylzinc to aldehydes catalyzed by new zinc-amides prepared by a rhodium-catalyzed asymmetric addition

作者：Yoshida Kazuhiro^*; Akashi Naohisa; Yanagisawa Akira

来源：Tetrahedron: Asymmetry , 2011, 22(11): 1225-1230.

DOI：10.1016/j.tetasy.2011.06.031

A new chiral zinc-amide 2s' was found to be an effective catalyst for the asymmetric addition of diethylzinc to aldehydes 3 through a screening method for asymmetric catalysts, in which two catalytic asymmetric reactions are connected. The chiral zinc catalyst can be readily prepared catalytically from achiral imine 1 by the chiral rhodium-diene complex mediated asymmetric addition of dimethylzinc.

• 出版日期2011-6-15