Facile strategy to well-defined water-soluble boronic acid (co)polymers

作者：Cambre Jennifer N; Roy Debashish; Gondi Sudershan R; Sumerlin Brent S^*

来源：Journal of the American Chemical Society, 2007, 129(34): 10348-+.

DOI：10.1021/ja074239s

A facile route to well-defined boronic acid (co)polymers from stable and easily manipulated boronic ester monomers is presented. The polymerization of 4-pinacolatoborylstyrene by reversible addition-fragmentation chain transfer (RAFT) yielded polymeric boronic acid precursors. Selection of stoichiometry allowed tuning of polymerization kinetics and targeting specific molecular weights in the range of M-n = 17000-32000 g/mol. The resulting low polydispersity poly(4-pinacolatoborylstyrene) homopolymers were employed as macro-chain transfer agents for block copolymerization with N,N-dimethylacrylamide to yield amphiphilic block copolymers that formed micelles in aqueous media. The pinacol ester derivatized (co)polymers were easily deprotected by a mild and convenient strategy to yield free boronic acid polymers.

• 出版日期2007-8-29