A practical nickel-catalyzed reductive alkylation of amidophenyl bromides

作者：Liu, Xuge; Yang, Zhilin; Li, Ya-Min; Yang, Fan; Feng, Liang; Wang, Nengzhong; Ma, Debiao; Chang, Kwen-Jen; Shen, Yuehai^*

来源：Tetrahedron, 2014, 70(50): 9522-9529.

DOI：10.1016/j.tet.2014.10.061

• Reductive coupling
• Nickel
• Amidophenyl bromide

A modified Weix's reductive coupling for alkylation of amidoaryl bromides based on Ni(COD)(2) precatalyst and 2,2'-dipyridyl ligand was developed. This reaction is reliable for amidophenyl bromides and gives yields up to 87%, and is potentially useful in the synthesis of amidophenyl-containing molecules.

• 出版日期2014-12-16
• 单位昆明理工大学