A follow-up study on thyroid aspirates reported as atypia of undetermined significance/follicular lesion of undetermined significance and follicular neoplasm/suspicious for follicular neoplasm: A multicenter study from the Arabian Gulf region

作者：Al Abbadi Mousa A; Shareef Sameera Q; Yousef Mohammad M; Almasri Nidal M; Mustafa Huda E; Aljawad Hameed; Ali Jassim A; Groves Alan; Alsaihati Yasmen

来源：Diagnostic Cytopathology, 2017, 45(11): 983-988.

DOI：10.1002/dc.23805

<jats:sec><jats:title>Objective</jats:title><jats:p>This is a multicenter study which was conducted to evaluate the follow‐up on thyroid aspirate cases with atypia of undetermined significance/follicular cells of undetermined significance (AUS/FLUS) and follicular neoplasm or suspicious for follicular neoplasm (FN/SFN) using the Bethesda system for reporting thyroid cytology (TBSRTC).</jats:p></jats:sec><jats:sec><jats:title>Materials and Methods</jats:title><jats:p>The archival materials of all thyroid fine‐needle aspirates over a 5‐year period were retrieved from 3 institutions in the Arabian Gulf Region. All cytology slides and follow‐up material for cases interpreted as AUS/FLUS and FN/SFN were reviewed. The revised diagnoses and follow‐up were recorded. Analysis of risk of malignancy was calculated for the 2 entities.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>A total number of 2592 thyroid fine‐needle aspirates were performed, out of which AUS/FLUS was found in 115 (4.4%) while FN/SFN in 39 (1.5%). Follow‐up by surgery or repeat FNA was conducted on 42 (27%) and 10 (7%) patients on these 2 categories, respectively. The risk of malignancy was found to be 29% and 45%, respectively.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>The risk of malignancy for AUS/FLUS and FN/SFN are 29% and 45%, respectively. This risk of malignancy in our study is on the higher range of that reported in the literature.</jats:p></jats:sec>

• 出版日期2017-11