科研之友
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摘要
Very elderly patients have not been well-represented in the randomized trials that established the benefits of cardiac resynchronization therapy (CRT) in heart failure (HF) patients. We therefore compared clinical outcomes in CRT-defibrillator (CRT-D) recipients a parts per thousand yen80 and < 80 years old. We compared mortality and time to first appropriate shock in 258 consecutive CRT-D patients a parts per thousand yen80 years old with New York Heart Association II-IV HF, left ventricular ejection fraction a parts per thousand currency sign35%, QRS duration a parts per thousand yen120 ms, and no prior sustained ventricular tachyarrhythmias to 1058 patients < 80 years old implanted with CRT-D during the same timeframe. Comorbidities and medical therapy differed significantly between the groups. During 52 +/- 36 months, 123 (48%) patients a parts per thousand yen80 and 474 (45%) patients < 80 died; mortality was significantly higher among patients a parts per thousand yen80 [corrected hazard ratio (HR) 1.39, 95% confidence interval (CI) 1.12-1.72; P = 0.003]. Among 258 patients a parts per thousand yen80 with device follow-up, only 20 (8%) received an appropriate shock compared with 172 (17%) shocks in 1053 patients < 80 years old. Time to first appropriate shock was significantly shorter in patients < 80 (corrected HR 0.51, 95% CI 0.30-0.87, P = 0.013). Older patients experienced 14 inappropriate shocks, and while life-threatening device complications were rare, complications related to the high-power components of the CRT-D system were not infrequent (n = 11). Mortality among CRT-D recipients a parts per thousand yen80 years old is higher than in younger patients but is not excessive. The risk of appropriate device shocks in older patients is relatively low and significantly less than in younger patients. These observations suggest that CRT-pacemakers should be given due consideration in elderly HF patients.
- 出版日期2016-3-1
