Novel Biomarkers to Predict Response and Prognosis in Localized Bladder Cancer

作者：Lucca Ilaria; de Martino Michela; Klatte Tobias; Shariat Shahrokh F^*

来源：Urologic Clinics of North America, 2015, 42(2): 225-+.

DOI：10.1016/j.ucl.2015.01.004

This review summarizes recent developments in diagnostic and prognostic biomarkers for nonmuscle invasive bladder cancer (NMIBC). Although the number of new biomarkers increases continuously, none are included in practice guidelines. Most NMIBC biomarkers show a higher sensitivity than urinary cytology, but lower specificity. Some protein and chromosome markers have been approved for screening and follow-up of patients in combination with cystoscopy. The long interval required for validation, testing, and approval of the assays and the lack of standardization could explain present issues in biomarker research. To enhance the development of new biomarkers, a more structured approach is required.

• 出版日期2015-5