A DNA-Based Archival Storage System

作者：Bornhol James^*; Lopez Randolph; Carmean Douglas M; Ceze Luis; Seelig Georg; Strauss Karin

来源：ACM Sigplan Notices, 2016, 51(4): 637-649.

DOI：10.1145/2872362.2872397

• Archival storage
• molecular computing
• DNA

Demand for data storage is growing exponentially, but the capacity of existing storage media is not keeping up. Using DNA to archive data is an attractive possibility because it is extremely dense, with a raw limit of 1 exabyte/mm(3) (10(9) GB/mm(3)), and long-lasting, with observed half-life of over 500 years.
This paper presents an architecture for a DNA-based archival storage system. It is structured as a key-value store, and leverages common biochemical techniques to provide random access. We also propose a new encoding scheme that offers controllable redundancy, trading off reliability for density. We demonstrate feasibility, random access, and robustness of the proposed encoding with wet lab experiments involving 151 kB of synthesized DNA and a 42 kB random-access subset, and simulation experiments of larger sets calibrated to the wet lab experiments. Finally, we highlight trends in biotechnology that indicate the impending practicality of DNA storage for much larger datasets.

• 出版日期2016-4
• 单位Microsoft