Mapping for Dyslexia and Related Cognitive Trait Loci Provides Strong Evidence for Further Risk Genes on Chromosome 6p21

作者：Koenig Inke R; Schumacher Johannes; Hoffmann Per; Kleensang Andre; Ludwig Kerstin U; Grimm Tiemo; Neuhoff Nina; Preis Maike; Roeske Darina; Warnke Andreas; Propping Peter; Remschmidt Helmut; Noethen Markus M; Ziegler Andreas; Mueller Myhsok Bertram; Schulte Koerne Gerd^*

来源：American Journal of Medical Genetics Part B-Neuropsychiatric Genetics, 2011, 156B(1): 36-43.

DOI：10.1002/ajmg.b.31135

• dyslexia
• genome scan
• linkage
• DYX2
• DCDC2
• KIAA0319

In a genome-wide linkage scan, we aimed at mapping risk loci for dyslexia in the German population. Our sample comprised 1,030 individuals from 246 dyslexia families which were recruited through a single-proband sib pair study design and a detailed assessment of dyslexia and related cognitive traits. We found evidence for a major dyslexia locus on chromosome 6p21. The cognitive trait rapid naming (objects/colors) produced a genome-wide significant LOD score of 5.87 (P = 1.00 x 10(-7)) and the implicated 6p-risk region spans around 10Mb. Although our finding maps close to DYX2, where the dyslexia candidate genes DCDC2 and KIAA0319 have already been identified, our data point to the presence of an additional risk gene in this region and are highlighting the impact of 6p21 in dyslexia and related cognitive traits.

• 出版日期2011-1
• 单位河北医科大学