Mouse models in fracture healing

作者：Ignatius A^*; Roentgen V; Bindl R; Recknagel S; Wehner T; Claes L; Jakob F; Schinke T; Amling M

来源：Osteologie, 2011, 20(1): 34-40.

• Mouse model
• fracture healing
• fracture model

Mouse models are increasingly used for fracture healing studies. Many inbred strains are available. The inbred strains significantly differ in bone phenotype and healing characteristics. Furthermore, also in mice standardized and mechanically controlled fracture healing models are obligate, because the mechanical conditions considerably influence the fracture healing outcome. Standardized fracture fixation techniques for the mouse are a technical challenge due to the small skeleton. However, in the meantime several different fixation devices are commercially available for the mouse femur allowing controlled fracture healing studies. Intramedullary nails, plates and external fixators can be used. All devices have various advantages and disadvantages, which should be regarded, dependeding on the scientific question to be answered. By these methodical improvements genetically modified mouse models can be used for fracture healing research. By deletion, over-expression or ectopic expression of a gene of interest its physiological or pathological role or its pharmacological effect can be investigated. Therefore, mouse models represent a very worthwhile tool for fracture healing research, even if the results have to be checked in large animal models and in human.

• 出版日期2011