Health and nutritional status of Wistar rats following subchronic exposure to CV127 soybeans

作者：Chukwudebe Amechi^*; Privalle Laura; Reed Andrew; Wandelt Christine; Contri Daniela; Dammann Martina; Groeters Sibylle; Kaspers Uwe; Strauss Volker; van Ravenzwaay Bennard

来源：Food and Chemical Toxicology, 2012, 50(3-4): 956-971.

DOI：10.1016/j.fct.2011.11.034

• BPS-CV127
• Imidazolinones
• Acetohydroxyacid synthase
• AHAS gene
• GM subchronic feeding study
• Whole food subchronic toxicity study

This subchronic duration feeding study evaluated the nutritional and health status of rats fed diets containing CV127 at incorporation levels of 11% and 33%. For control comparisons, rats were also exposed to similar incorporation levels of the near isogenic conventional soybean variety (Conquista) and two other conventional soybean varieties (Monsoy, Coodetec). In spite of phenotypic differences among these four soybean varieties, there were no quantitative differences in their respective proximate and other compositional properties, including proteins, amino acids, antinutrients and nutritional cofactors. All diets were prepared by blending the respective processed soybean meal with ground Kliba maintenance meal at high (33%) and low (11%) incorporation levels, and the blended diets were fed to Wistar rats for about 91 days. Although there were some isolated parameters indicating statistically significant changes, these lacked consistency and a plausible mechanism and were thus assessed to be incidental. The totality of results demonstrate that CV127 soybeans are similar with respect to their nutritional value and systemic effects as its near isogenic conventional counterpart, as well as other conventional soybean varieties. Hence, introduction of AHAS gene into soybeans does not substantially alter its compositional properties, nor adversely affect its nutritional or safety status to mammals.

• 出版日期2012-4