Update on the safety of second generation antipsychotics in youths: a call for collaboration among paediatricians and child psychiatrists

作者：Pisano Simone; Catone Gennaro; Veltri Stefania; Lanzara Valentina; Pozzi Marco; Clementi Emilio; Iuliano Raffaella; Riccio Maria Pia; Radice Sonia; Molteni Massimo; Capuano Annalisa; Gritti Antonella; Coppola Giangennaro; Milone Annarita; Bravaccio Carmela; Masi Gabriele

来源：Italian Journal of Pediatrics, 2016, 42(1): 51.

DOI：10.1186/s13052-016-0259-2

• Children
• Adolescents
• Antipsychotics
• Adverse events

During the past decade, a substantial increase in the use of second generation antipsychotics (SGAs) has occurred for a number of juvenile psychiatric disorders, often as off-label prescriptions. Although they were thought to be safer than older, first generation antipsychotics, mainly due to a lower risk of neurological adverse reactions, recent studies have raised significant concerns regarding their safety regarding metabolic, endocrinological and cardiovascular side effects. Aim of this paper is to update with a narrative review, the latest findings on safety of SGAs in youths. Results suggest that different SGAs may present different safety profiles. Metabolic adverse events are the most frequent and troublesome, with increasing evidences of heightened risk for type II diabetes mellitus. Results are discussed with specific emphasis on possible strategies of an active monitoring, which could enable both paediatricians and child psychiatrists to a possible prevention, early detection, and a timely management of such effects.

• 出版日期2016-5-21