Dihydroxo-bridged dimeric Cu(II) system containing sandwiched non-coordinating phenylacetate anion: Crystal structure, spectroscopic, anti-bacterial, anti-fungal and DNA-binding studies of [(Phen)(H2O)Cu(OH)(2)Cu(H2O)(phen)2L center dot 6H(2)O: (HL = phenylacetic acid; phen=1,10-phenanthroline)

作者：Iqbal Muhammad^*; Ali Saqib; Tahir Muhammad Nawaz; Shah Naseer Ali

来源：Journal of Molecular Structure, 2017, 1143: 23-30.

DOI：10.1016/j.molstruc.2017.04.084

• Copper(II) bridged complex
• Crystal structure
• DNA-Binding
• Anti-bacterial
• Anti-fungal study

This paper reports the synthesis, X-ray crystal structure, DNA-binding, antibacterial and antifungal studies of a rare dihydroxo-bridged dinuclear copper(II) complex including 1,10-phenanthroline (Phen) ligands and phenylacetate (L) anions, [Cu-2(Phen)(2)(OH)(2)(H2O)2]center dot 2L center dot 6H(2)O. Structural data revealed distorted square-pyramidal geometry for each copper(II) atom with the basal plane formed by the two nitrogen atoms of the phenantroline ligand and the oxygen atoms of two bridging hydroxyl groups. The apical positions are filled by the oxygen atom from a water molecule. This forms a centrosymmetric cationic dimer where the uncoordinated phenylacetate ligands serve to balance the electrical charge. The dimers interact by means of hydrogen bonds aided by the coordinated as well as uncoordinated water molecules and phenyl-acetate moieties in the crystal lattice. The binding ability of the complex with salmon sperm DNA was determined using cyclic voltammetry and absorption spectroscopy yielding binding constants 2.426 x 10(4) M-1 and 1.399 x 10(4) M-1, respectively. The complex was screened against two Gram-positive (Micrococcus luteus and Bacillus subtilis) and one Gram-negative (Escherichia coli) bacterial strains exhibiting significant activity against all the three strains. The complex exhibited significant, moderate and no activity against fungal strains Mucor piriformis, Helminthosporium solani and Aspergillus Niger, respectively. These preliminary tests indicate the competence of the complex towards the development of a potent biological drug.

• 出版日期2017-9-5