Adipocytokine Levels in Obese and Non-obese Subjects: an Observational Study

作者：Derosa Giuseppe^*; Fogari Elena; D' Angelo Angela; Bianchi Lucio; Bonaventura Aldo; Romano Davide; Maffioli Pamela

来源：Inflammation, 2013, 36(4): 914-920.

DOI：10.1007/s10753-013-9620-4

• adipocytokines
• adipose tissue
• inflammation
• insulin resistance
• obesity

We evaluated the levels of some inflammatory adipocytokines in 363 obese and 365 non-obese subjects. We measured: body mass index (BMI), waist circumference (WC), fasting plasma glucose, fasting plasma insulin (FPI), homeostasis model assessment (HOMA) index, blood pressure, lipid profile, retinol binding protein-4 (RBP-4), vaspin, omentin-1, leptin, interleukin-6 (IL-6), visfatin, resistin, adiponectin (ADN), adipsin, tumor necrosis factor-alpha (TNF-alpha), and high sensitivity C-reactive protein (Hs-CRP). We observed higher BMI, WC, FPI, HOMA index, TC, LDL-C, RBP-4, leptin, IL-6, adipsin, Hs-CRP, vaspin, resistin and TNF-alpha levels, and lower visfatin, and ADN levels in obese compared to non-obese subjects. Higher WC correlated with lower ADN and visfatin levels, and higher vaspin levels. Higher HOMA index correlated with higher resistin, adipsin, RBP-4, and leptin concentrations, while higher leptin levels correlated with higher TNF-alpha, Hs-CRP, and IL-6 concentration, and lower ADN values. We confirmed obese subjects%26apos; predisposition to develop dysmetabolic disease and hormonal dysfunctions.

• 出版日期2013-8