Obesity is associated with previous suicide attempts in bipolar disorder

作者：Gomes Fabiano A; Kauer Sant'Anna Marcia; Magalhaes Pedro V; Jacka Felice N; Dodd Seetal; Gama Clarissa S; Cunha Angelo; Berk Michael; Kapczinski Flavio^*

来源：Acta Neuropsychiatrica, 2010, 22(2): 63-67.

DOI：10.1111/j.1601-5215.2010.00452.x

• bipolar disorder
• obesity
• suicide

Objective: There is a paucity of data about risk factors for suicide attempts in bipolar disorder. The aim of this study is to examine the association between suicide attempts and obesity in people with bipolar disorder.
Methods: Two hundred fifty-five DSM-IV out-patients with bipolar disorder were consecutively recruited from the Bipolar Disorder Program at Hospital das Clinicas de Porto Alegre and the University Hospital at the Universidade Federal de Santa Maria, Brazil. Diagnosis and clinical variables were assessed with Structured Clinical Interview for DSM-IV-axis I (SCID I) and Program structured protocol. History of suicide attempts was obtained from multiple information sources including patients, relatives and review of medical records. Patients with body mass index (BMI) >= 30 were classified as obese.
Results: Over 30% of the sample was obese and over 50% had a history of suicide attempt. In the multivariate model, obese patients were nearly twice (OR = 1.97, 95% CI: 1.06-3.69, p = 0.03) as likely to have a history of suicide attempt(s).
Conclusion: Our results emphasise the relevance of obesity as an associated factor of suicide attempts in bipolar disorder. Obesity may be seen as correlate of severity and as such, must be considered in the comprehensive management of bipolar patients.