ADIPOSITY PERCENTAGE RELATIONSHIP WITH HORMONE RECEPTORS IMMUNOREACTIVE SCORE IN BREAST CANCER MEXICAN WOMEN

作者：Adriana Balderas Pena Luz Ma; Sat Munoz Daniel; Castro Cervantes Juan Manuel; Ramirez Orozco Ricardo Ernesto; Angeles Bueno Wenceslao Guillermo; Flores Marquez Maria Rosa; Macias Lopez Griselda Guadalupe; Ruiz Quezada Sandra Luz; Salcedo Rocha Ana Leticia; Garcia de Alba Garcia Javier Eduardo; Solano Murillo Pedro

来源：Nutricion Hospitalaria, 2013, 28(4): 1321-1329.

DOI：10.3305/nh.2013.28.4.6470

• Adiposity percentage
• Breast cancer
• Estrogen receptors
• Progesterone receptors

Introduction: Adipose tissue is an important estrogen resource and they are involved in breast cancer development.
Objective: To establish the relationship between adiposity percentage and the estrogen and progesterone receptors immunoreactive score in Mexican women with breast cancer.
Methods: This is a transversal and analytical study. We identified breast cancer women with cancer histologic diagnosis. We calculated: adiposity percentage and immunoreactive score. We performed correlation analysis between adiposity percentage, body mass index, diabetes mellitus and arterial hypertension, with estrogen and progesterone receptors in breast cancer samples. We perform logistic regression and Odds Ratio estimations.
Results: We studied 43 patients with breast cancer and we observed association between adiposity percentage and estrogen and progesterone immnunoreactive score (rP 0.470; p 0.003 and rP 0.328; p 0.042, respectively). The most important risk factor in breast cancer positive to estrogen receptors was obesity (OR 19.1, IC95% 2.1 a 169.1, p 0.008), and previous obesity in breast cancer positive to progesterone receptors (OR 20.7, IC95% 2.3 a 185.9, p 0.007).
Discussion: Adiposity percentage is an important risk factor to develop breast cancer positive to hormone receptors related with the risk of breast cancer positive to hormonal receptors.

• 出版日期2013-8