No evidence for an anti-inflammatory effect of escitalopram intervention in healthy individuals with a family history of depression

作者：Haastrup Eva^*; Knorr Ulla; Erikstrup Christian; Kessing Lars Vedel; Ullum Henrik

来源：Journal of Neuroimmunology, 2012, 243(1-2): 69-72.

DOI：10.1016/j.jneuroim.2011.12.006

• Escitalopram
• Cytokines
• Clinical trial
• Healthy
• Genetic disposition for depression

Inflammation may contribute to the pathogenesis of depression and antidepressants are hypothesised to have an anti-inflammatory effect. %26lt;br%26gt;In this randomised double-blinded trial we investigated the cytokine levels in supernatants of stimulated whole blood samples from first degree relatives to patients with depression randomised to a single daily dose of either 10 mg escitalopram or placebo for four weeks. %26lt;br%26gt;No significant differences were found in any of the cytokine levels between the participants treated with escitalopram (n=21) or placebo (n=23). %26lt;br%26gt;Our data does thus not support the hypothesis of a global anti-inflammatory effect of escitalopram on cytokines in healthy subjects.

• 出版日期2012-2-29