The reactivity of alpha-oxoaldehyde with reactive oxygen species in diabetes complications

作者：Matsumura Yuriko^*; Iwasawa Atsuo; Kobayashi Toshihiro; Kamachi Toshiaki; Ozawa Toshihiko; Kohno Masahiro

来源：Journal of Clinical Biochemistry and Nutrition, 2013, 52(2): 128-132.

DOI：10.3164/jcbn.12-70

• reactive oxygen species
• glucose metabolites
• ESR
• hydroxyl radical
• alpha-oxoaldehyde

The reactions of three alpha-oxoaldehydes (methylglyoxal, glyoxal, and pyruvic acid) with hydroxyl radicals generated by sonolysis of water were investigated using an electron spin resonance (electron paramagnetic resonance) spin-trapping method, and their reaction kinetics were investigated. It is apparent from our experimental results that methylglyoxal exhibits the highest reactivity of the three a-oxoaldehydes. These a-oxoaldehydes can react with hydroxyl radicals faster than other well-known antioxidants can. The reactivity of hydroxyl radicals is higher than that of hydrogen peroxides.

• 出版日期2013-3-1