Association between the interleukin-18 promoter polymorphism and pulmonary tuberculosis in a Korean population

作者：Lee S H; Choi I H; Jeon Y K; Park S J; Lee H K; Lee Y M; Chang C L; Kim Y S; Lee M K; Park S K

来源：International Journal of Tuberculosis and Lung Disease, 2011, 15(9): 1246-1251.

DOI：10.5588/ijtld.11.0031

• tuberculosis
• interleukin-18
• single nucleotide polymorphism
• cavity

OBJECTIVE: To examine the role of the -667G/T, -618A/C and -148G/C single nucleotide polymorphisms in the promoter region of the human interleukin (11) 18 gene in the development of pulmonary tuberculosis (PTB), and its radiographic characteristics and severity.
DESIGN: Differences in the allele and genotype distributions of the -667G/T, -618A/C, and -148G/C polymorphisms between 251 patients with PTB and 225 healthy controls, between patients with single- and multilobe involvement, and between patients with and without cavities were explored. Serum IL-18 levels were measured using an enzyme-linked immunosorbent assay.
RESULTS: The -148G/G genotype was more common in patients with cavities than in those without (82.8% vs. 70.9%, P = 0.04), but an analogous trend was not observed for the -667G/T and -618A/C genotypes. However, there were no significant differences in allele and genotype distributions between patients with PTB and healthy controls, or between patients with single- and multilobe involvement (P>0.05). Serum IL-18 levels were higher in patients with cavities (P = 0.01) and in patients with the -148G/G genotype (P = 0.02).
CONCLUSION: Considering serum IL-18 levels, the -148G/G genotype is associated with a cavitary formation of PTB rather than its development.

• 出版日期2011-9