A concise synthetic approach to diversely functionalized alpha-methylene-gamma-butyrolactones

作者：Liberge Gwenaelle; Lebrun Stephane; Couture Axel; Grandclaudon Pierre^*

来源：Comptes Rendus Chimie, 2011, 14(10): 916-926.

DOI：10.1016/j.crci.2011.03.006

• Lactones
• Cyclization
• Transesterification
• Enolate
• Elimination

A new synthetic approach for the elaboration of diversely functionalized alpha-methylene-gamma-butyrolactones has been developed. The first step was the preliminary construction of the lactone ring system equipped with easily manageable functionalities. As the key step, the ultimate deprotonation/methoxymethylation/beta-elimination sequence allowed installation of the exocyclic olefinic moiety and then permitted chemical transformation of the above-mentioned functionalities to complete the synthesis of the title compounds.

• 出版日期2011-10