Activity Energy Expenditure and Mobility Limitation in Older Adults: Differential Associations by Sex

作者：Manini Todd M^*; Everhart James E; Patel Kushang V; Schoeller Dale A; Cummings Steve; Mackey Dawn C; Bauer Douglas C; Simonsick Eleanor M; Colbert Lisa H; Visser Marjolein; Tylavsky Frances; Newman Anne B; Harris Tamara B

来源：American Journal of Epidemiology, 2009, 169(12): 1507-1516.

DOI：10.1093/aje/kwp069

• aging
• disability evaluation
• energy metabolism
• exercise
• mobility limitation
• motor activity
• sex

In this study, the authors aimed to determine whether higher activity energy expenditure, assessed by using doubly labeled water, was associated with a reduced decline in mobility limitation among 248 older community-dwelling US adults aged 70-82 years enrolled in 1998-1999. Activity energy expenditure was calculated as total energy expenditure (assessed over 2 weeks by using doubly labeled water) minus resting metabolic rate (measured with indirect calorimetry), with adjustment for the thermic effect of food. Across sex-specific tertiles of activity energy expenditure, men in the lowest activity group experienced twice the rate of mobility limitation as men in the highest activity group (41% (n = 18) vs. 18% (n = 8)). Conversely, women in the lowest and highest activity groups exhibited similarly high rates of mobility limitation (40% (n = 16) vs. 38% (n = 15)). After adjustment for potential confounders, men with higher activity energy expenditure levels continued to show reduced risk of mobility limitation (per standard deviation (284 kcal/day): hazard ratio = 0.61, 95% confidence interval: 0.41, 0.92). Women showed no association (per standard deviation (226 kcal/day): hazard ratio = 1.34, 95% confidence interval: 0.98, 1.85). Greater energy expenditure from any and all physical activity was significantly associated with reduced risk of developing mobility limitation among men, but not among women.

• 出版日期2009-6-15