A chiral bicyclo[2.2.2]octa-2,5-diene ligand substituted with the ferrocenyl group and its use for rhodium-catalyzed asymmetric 1,4-addition reactions

作者：Zhou Bo^*; So Chau Ming; Lu Yixin; Hayashi Tamio

来源：Organic Chemistry Frontiers, 2015, 2(2): 127-132.

DOI：10.1039/c4qo00292j

A chiral diene, (R,R)-Fc, Ph-bod, which bears the ferrocenyl (Fc) group and the phenyl (Ph) group on the bicyclo[2.2.2]octa-2,5-diene skeleton, has been synthesized, and its rhodium complex was examined as a catalyst for the asymmetric 1,4-addition of arylboronic acids to alpha,beta-unsaturated ketones. Its enantio-selectivity was generally higher than that observed with (R,R)-Ph-bod, which is C-2 symmetric with two phenyl groups.

• 出版日期2015