科研之友
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摘要
A novel method for the synthesis of alpha-sialosides using a newly developed 5-ureido-modified sialyl donor is reported. The donor was found to be useful for alpha-selective sialidation with various glycosyl acceptors, forming alpha(2,6)Glc, alpha(2,6)Gal, and alpha(2,3)Gal linkages in excellent yield and with stereoselectivity. Furthermore, alpha-sialoside was easily isolated from the reaction mixture by the 1,5-lactamization method under mild conditions. Successful application of the C5-ureido sialyl donor to the synthesis of a sialoside confirmed the usefulness of the present method.
- 出版日期2016-3-18
