An approach to dihydroisoindolobenzodiazepinones-three-dimensional molecular frameworks

作者：Yaremenko Anatoliy G; Shelyakin Vyacheslav V^*; Volochnyuk Dmitriy M; Rusanov Eduard B; Grygorenko Oleksandr O

来源：Tetrahedron Letters, 2013, 54(10): 1195-1197.

DOI：10.1016/j.tetlet.2012.12.065

• Condensation
• Isoindoles
• Benzodiazepines
• Three-dimensional heterocycles

A concise two-step procedure is developed for the preparation of dihydroisoindolobenzodiazepinones, which represent derivatives of three-dimensional molecular frameworks derived from classical privileged structures of medicinal chemistry. The method commences from the readily available starting materials (i.e., 2-formylbenzoic acid, o-phenylenediamine, and various ketones) and enables the synthesis of the title compounds in 58-82% overall yields.

• 出版日期2013-3-6