Genetic risk and age in Parkinson's disease: Continuum not stratum

作者：Nalls Mike A; Escott Price Valentina; Williams Nigel M; Lubbe Steven; Keller Margaux F; Morris Huw R; Singleton Andrew B^*

来源：Movement Disorders, 2015, 30(6): 850-854.

DOI：10.1002/mds.26192

• Parkinson's disease
• genetics
• age at onset
• statistics

BackgroundRecent genomewide association study meta-analyses have identified 28 loci associated with risk of Parkinson's disease (PD). We sought to investigate whether these genetic risk factors are associated with PD age at onset.
MethodsGenetic risk scores from these loci were calculated for 6,249 cases. Linear regression tested associations between cumulative genetic risk and PD age at onset.
ResultsIncreasing genetic risk scores were associated with earlier age at onset (beta=-0.10, P=2.92 x 10(-8), adjusted r(2)=0.27). Single standard deviation increase in genetic risk score is associated with 37.44 d earlier age at onset. Highest genetic risk was found at 31 to 60 y, onset slightly below average age at onset (AAO).
ConclusionsCommon genetic risk factors have a small but consistent association with AAO in PD.

• 出版日期2015-5